1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl-
DC661
CAS: 1872387-43-3
Molecular Formula: C31H39Cl2N5
1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl- - Names and Identifiers
| Name | DC661 |
| Synonyms | DC661 DC-661 DC 661 N'-(7-Chloro-4-quinolinyl)-N-{6-[(7-chloro-4-quinolinyl)amino]hexyl}-N-methyl-1,6-hexanediamine 1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl- |
| CAS | 1872387-43-3 |
1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl- - Physico-chemical Properties
| Molecular Formula | C31H39Cl2N5 |
| Molar Mass | 552.58 |
| Density | 1.210±0.06 g/cm3(Predicted) |
| Boling Point | 726.8±60.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 9.77±0.50(Predicted) |
| Storage Condition | -20℃ |
| Use | DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor. DC661 inhibits autophagy. DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ). |
| Target | PPT1, autophagy |
| In vitro study | Treatment of melanoma cells with DC661 caused an accumulation of the autophagic vesicle marker LC3B-II, an accumulation effect that was more pronounced than Lys05 or HCQ, and at lower concentrations. When the concentration of DC661 was greater than 10 μm, all cells died. Compared with HCQ and Lys05, DC661 was more effective in suppressing autophagic flux in melanoma cells expressing mCherry-eGFP-LC3B reporter gene, and in melanoma cells expressing GFP-LC3B reporter gene, higher levels of free GFP were expressed. DC661 can cause a more significant lysosomal deacidification effect. In a variety of cancer cell lines (including colon cancer cells and pancreatic cancer cells), The IC50 of DC661 was 100 times lower than that of HCQ after 72 hours of drug incubation. In BRAF-mutated melanoma cell lines, DC661 was more effective in inhibiting the clonal growth of long-term melanoma cells and inducing more apoptosis than Lys05, HCQ, or BRAF/MEK dual inhibition conditions. |
| In vivo study | In the HT29 xenograft model, intraperitoneal injection of 3 mg/kg DC661 resulted in a significant reduction in tumor volume, and the daily tumor growth rate was completely suppressed by several times. But it did not affect the body weight of mice. |
1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl- - Reference
| Reference Show more | [1]. Rebecca VW, et al. PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. ancer Discov. 2019 Feb;9(2):220-229. |
1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.81 ml | 9.048 ml | 18.097 ml |
| 5 mM | 0.362 ml | 1.81 ml | 3.619 ml |
| 10 mM | 0.181 ml | 0.905 ml | 1.81 ml |
| 5 mM | 0.036 ml | 0.181 ml | 0.362 ml |
Last Update：2024-01-02 23:10:35
1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl- - Cell Experiment
Cell lines: A375P cellsConcentrations: 0.1, 0.3, 1, 3, 10 μMIncubation Time: 6 hoursMethod:A375P cells are treated with doses of HCQ, Lys05, or DC661 for 6 hours before lysates are immunoblotted.
Last Update：2023-08-16 21:32:38
1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl- - Animal Experiment
Animal Models: HT29 colorectal xenograftDosages: 3 mg/kgAdministration: i.p.
Last Update：2023-08-16 21:32:38
1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl- - Introduction
DC661 is an organic compound fully known as N,N'-methylenebis (2,2, 6,6-tetramethyl-4-piperidinamine). Its chemical formula is C16H32N2 and its molecular weight is 256.44g/mol.
DC661 is mainly used as organic synthesis and catalyst. It has a wide range of applications in the synthesis of organic compounds, polymers, polymer toughening agents and so on. In organic synthesis, it is often used as a curing agent, oxidant and polymerization catalyst.
The preparation method of DC661 is relatively simple, generally obtained by oxidizing ethylamine and O-cyclobutane to generate cyclobutane Dione and then nucleophilic addition reaction with tetramethylamine.
Regarding safety information, DC661 is a relatively safe compound for researchers and the environment, and has low toxicity. However, during use, care should still be taken to avoid prolonged skin contact, inhalation and intake. Appropriate protective equipment, such as lab gloves, safety glasses and face shields, should be worn during operation. During storage and handling, avoid contact with oxidants and strong acids, and store in a dry and cool place. The waste shall be disposed in accordance with relevant laws and regulations and shall not be dumped at will. For specific use and handling issues, it is recommended to refer to the safety data sheet (SDS) of this compound or to consult a relevant expert.
DC661 is mainly used as organic synthesis and catalyst. It has a wide range of applications in the synthesis of organic compounds, polymers, polymer toughening agents and so on. In organic synthesis, it is often used as a curing agent, oxidant and polymerization catalyst.
The preparation method of DC661 is relatively simple, generally obtained by oxidizing ethylamine and O-cyclobutane to generate cyclobutane Dione and then nucleophilic addition reaction with tetramethylamine.
Regarding safety information, DC661 is a relatively safe compound for researchers and the environment, and has low toxicity. However, during use, care should still be taken to avoid prolonged skin contact, inhalation and intake. Appropriate protective equipment, such as lab gloves, safety glasses and face shields, should be worn during operation. During storage and handling, avoid contact with oxidants and strong acids, and store in a dry and cool place. The waste shall be disposed in accordance with relevant laws and regulations and shall not be dumped at will. For specific use and handling issues, it is recommended to refer to the safety data sheet (SDS) of this compound or to consult a relevant expert.
Last Update：2024-04-10 22:29:15
![1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl-](http://res.chembk.com/assets/images/structure/190493.gif)
Supplier List
Spot supply
Product Name: DC661 Visit Supplier Webpage Request for quotationCAS: 1872387-43-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: DC661 Visit Supplier Webpage Request for quotationCAS: 1872387-43-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
1,6-Hexanediamine, N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl-
2200214-93-1
41239-36-5
2200214-93-1
41239-36-5